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LYRIC (also known as Metadherin), a positive regulator of EMT, can promote ferroptosis by inhibiting the expression of GPX4 and SLC3A2 ( 3.4 Ferroptosis influences intestinal diseases by affecting metabolism Multiple metabolic pathways can influence cellular susceptibility to ferroptosis (Table 5)

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ROS accumulation is associated with oxidative stress, causing damage to cellular components such as lipids, proteins, and DNA, contributing to tissue injury and dysfunction (3)

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